IL-7- and CCL19-secreting CAR-T cells (7 × 19 CAR-T) demonstrated enhanced expansion and migration capabilities in vitro, along with superior tumor-suppression abilities compared to conventional CAR-T cells in xenografts of hepatocellular carcinoma (HCC) cell lines, primary HCC tissue samples and pancreatic carcinoma (PC) cell lines. The gene discussed is CCL19; the disease is exocrine pancreatic carcinoma.