For example, a recombinant 53 kDa glycoprotein from TsES (rTsP53) displays anti-inflammatory characteristics and protects mice from endotoxemia induced by lipopolysaccharides (LPS) by reducing levels of pro-inflammatory agents (TNF-α, IL-1β, and IL-6) (42). This evidence concerns the gene TNF and serum lipopolysaccharide activity.