CXCL10 and neoplasm: Plasma sample analysis demonstrated a significant effect of the combination of agents on levels of IP-10 in both EL4-PAR and EL4-C8KO tumor-bearing mice at day 5 (Supplementary Fig. S9B) demonstrating that T cells can be recruited in both models, but that only in the model with increased levels of necroptosis is there a dramatic effect on tumor regression (Fig. 6).