Whole genome sequencing of isolates collected between October 2021 and September 2023 confirmed this concern, with 29 of 33 clonal isolates sharing the following genetic characteristics: ST121, resistance to fusidic acid conferred by fusB, resistance to mupirocin conferred by mupA and the presence of the virulence genes eta and etb. In a previous study on subpopulations of S. aureus CC121, isolates sampled from superficial infections (including staphylococcal scalded skin syndrome, bullous impetigo, exfoliative dermatitis, and conjunctivitis) clustered in the same clade, including EEFIC [16]. Here, EDNRA is linked to exfoliative dermatitis.