Furthermore, ORI impeded activation of ABL kinase along with RAF/MEK/ERK, Akt/mTOR, and STAT5 signaling pathways, and regulated BCL‐2/BAX expression to exhibit antileukemia effect on Ph(+) ALL SUP‐B15 cells (Guo et al., 2012a). This evidence concerns the gene BAX and acute lymphoblastic leukemia.