Daily carvacrol feeding (50 mg/kg/day) singly or combined with simvastatin (20 mg/kg/day) in rats with hyperlipidemia induced by injecting poloxamer 407 (500 mg/kg) resulted in hypolipidemic effects including decreasing total cholesterol (TC), triglycerides, low‐density lipoprotein (LDL), leptin, atherogenic index, and increasing adiponectin and high‐density lipoprotein (HDL). The gene discussed is ADIPOQ; the disease is hyperlipidemia.