Therefore, there is a growing interest in understanding the potential crosstalk between the VGLL3 and Hippo pathways in regulating sexual dimorphism in autoimmunity, exemplified by studies showing that VGLL3 drives IFN-β1 expression in fibroblast-like synoviocytes of RA patients by inhibiting TAZ1 expression [37]. This evidence concerns the gene VGLL3 and Autoimmunity.