Aside from IL-8, additional factors including IL-1β, CCL2, CXCL5, IL-17 and IL-18 also selectively recruit subsets of MDSCs from the vasculature into renal cell carcinoma (Najjar et al., 2017; Guan et al., 2018) while CCL3 and CCL5 are important for the retention of MDSCs in tumors (Kumar et al., 2016). Here, CXCL8 is linked to hereditary clear cell renal cell carcinoma.