VEGFA and neoplasm: The hypoxia in tumor regions that are farthest from the tumor vasculature initiates proangiogenic gene expression such as platelet-derived growth factors (PDGFs) (Kourembanas et al., 1990) and vascular endothelial growth factors (VEGFs) (Shweiki et al., 1992) via the hypoxia-inducible factor (HIF) transcription factors (Pugh and Ratcliffe, 2003).