A study in renal cell carcinoma demonstrated this large group of CD56hiCD16- NK cells express an array of pro-angiogenic factors including VEGF-A, VEGF-B, ANG-2, IL-6, IL-8, CCL3, CXCL1, CCR7 and CD146 receptor (Guan et al., 2020). Here, CCL3 is linked to hereditary clear cell renal cell carcinoma.