In ischemic stroke models, SNHG8 contributes to neuronal apoptosis, microglial activation, and neuroinflammation by sponging miR-449c-5p and miR-425-5p, resulting in the downstream regulation of sirtuin 1 (SIRT1) (Tian et al., 2021; Zhang et al., 2022). The gene discussed is SIRT1; the disease is ischemic stroke.