Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) confers a neuroprotective role in AD by promoting neurite outgrowth and inhibiting apoptosis, inflammation, and Aβ1-42 induced cytotoxicity by interacting with miR-125, -200a, -26a, -26b, and their downstream targets Prostaglandin-endoperoxide Synthase 2 (PTGS2), Cyclin-dependent Kinase 5 (CDK5), Forkhead Box Q1 (FOXQ1), and Receptor Tyrosine Kinase (RTK) EphA2 (Ma P. et al., 2019). The gene discussed is PTGS2; the disease is Alzheimer disease.