miR-7 is elevated in the cortex of AD patients and regulates critical insulin and Aβ metabolic genes, including ABCA1, insulin receptor (INSR), insulin receptor substrate 2 (IRS-2), insulin-degrading enzyme (IDE), and liver x receptor (LXR) (Fernández-de Frutos et al., 2019). The gene discussed is IDE; the disease is Alzheimer disease.