FOXO1 and neoplasm: Moreover, several studies have shown that the upregulation of the expression of some mechanosensitive cytoprotective genes such as manganese superoxide dismutase (SOD1), Sirtuin 1 (SIRT1), NF-E2-related factor 2 (Nrf2) and Transcription factor forkhead box protein O1 (FOXO1), is a necessary survival adaptation during tumor progression (Maiese et al., 2009; Park et al., 2012; Zhang et al., 2016; Xue et al., 2020; Eleutherio et al., 2021).