SERPING1 and hereditary angioedema: Hereditary angioedema (HAE) is a rare, life-threatening autosomal dominant genetic disorder caused by a deficient or dysfunctional C1 esterase inhibitor (C1-INH) (type 1 and type 2), leading to the overproduction of bradykinin and the development of recurrent subcutaneous or submucosal edema (1, 2).