One particular strategy of spirochetes involves direct binding to extracellular matrix components, in particular fibronectin and the participation of structural, highly diverse adhesins including BBK32, OspC, RevA, BB0347, CspA, and CspZ of Lyme disease spirochetes (15, 33, 46–53) and the BBK32 orthologs BHA007, FbpA, and FbpC of RF spirochetes (10, 12, 18). Here, FN1 is linked to Lyme disease.