CARIR-z THP-1 had significantly increased phagocytosis activity against both the PD-L1+ tumor cell lines, the triple negative breast cancer (TNBC) line MDA-MB-231 and non-small-cell lung cancer (NSCLC) line NCI-H358, as compared to either the nonmodified or CARIR-Δz-THP-1 macrophages conditions. Here, CD274 is linked to neoplasm.