Notably, four of the twelve significantly regulated miRNAs (miR-323a-3p, miR-382-5p, miR-370-3p, miR-134-5p), are located within the DLK1-DIO3 domain, which has been identified as a cancer-associated genomic region on the human chromosome 14 (14q32) which harbors in total 53 miRNAs. Here, DIO3 is linked to cancer.