Various activating and inhibitory receptors on NK cells have been targeted by NK cell engagers to improve NK cells in cancer eradication, including CD16a, CD160, CD96, NKG2A, NKG2D, NKG2C, Nkp30, Nkp46, Nkp80, KIR2DS/KIR3DS, KIR2DL/KIR2DS, DNAM-1, 2B4, PD-1, IL-2/IL-15, TIGIT, and TIM-3 (95). The gene discussed is NCR1; the disease is cancer.