demonstrated that anti-CD123-2B4-CD3 CAR-NK was able to increase NK cell persistence by revealing high proliferative and activated transcriptomic NK cell signatures and enhance anti-tumor ability against acute myeloid leukaemia (AML) in vitro and in vivo when co-expressed with secretory IL-15 (sIL-15) (73). Here, IL15 is linked to acute myeloid leukemia.