CXCR1 and neoplasm: To revitalize NK cells from the suppressive tumor microenvironment, SX-682 which is an inhibitor targeting chemokine receptor 1/2 (CXCR1/2) showed promising inhibition towards suppressive myeloid-derived suppressor cells (MDSCs), thus preventing them from infiltrating into tumor microenvironment of head and neck cancer and deactivating NK cells (100).