However, LOX has little effect on the activity of MMP in rat aortic smooth muscle cells 347, and even in gastric cancer 348, cervical cancer 349, colorectal cancer 350, non-small cell lung cancer 351, breast cancer 352, LOX is positively correlated with MMPs or increases MMPs activity, while in liver cancer, lysyl oxidase propeptide (LOX-PP) inhibits liver cancer cell migration by down-regulating MMPs expression 353. This evidence concerns the gene LOX and colorectal cancer.