BECN1 and Familial prostate cancer: In terms of autophagy, FOXM1 is shown to up-regulate LC3-II/LC3-I and beclin-1 and promote autophagy in bladder cancer 184, liver cancer 185, prostate cancer 186, and gastric cancer 187, and it is determined in triple-negative breast cancer cells that FOXM1 directly binds to the promoter of LC3 and beclin-1 genes to promote transcription 188.