SACK1H and pachyonychia congenita: Furthermore, lncRNA family with sequence similarity 83 member H antisense RNA 1 (FAM83H-AS1) is similar to TSLNC8 and FGD5-AS1 in that it can up-regulate the level of β-catenin to activate Wnt/β-catenin signaling, but the difference is that FAM83H-AS1 induces FAM83H expression by stabilizing FAM83H mRNA, thus enhances the ability of FAM83H binding to β-catenin and inhibiting its degradation, and ultimately promotes the proliferation, invasion and metastasis of PC cells 51.