In the study of Chen et al.68, the knockdown of lncRNA cyclin dependent kinase inhibitor 2B antisense RNA 1 (ANRIL) up-regulated miR-181a and down-regulated HMGB1 at mRNA and protein levels, which made cancer cells sensitive to gemcitabine and showed inhibition of tumor activity and promotion of autophagy. This evidence concerns the gene HMGB1 and cancer.