Similarly, miR-195-5p is the target of lncRNA LINC00473, which can drive the progression of PC 130, and WIPI2, a key autophagy regulator 131, can be up-regulated by lncRNA ceramide synthase 6 antisense RNA 1 (CERS6-AS1) to regulate the migration and apoptosis of PC cells via miR-195-5p 132. This evidence concerns the gene WIPI2 and pachyonychia congenita.