The high level of autophagy is associated with the abnormal expression of MIT/TFE family in PC, among which melanocyte inducing transcription factor (MITF), transcription factor binding to IGHM enhancer 3 (TFE3) and transcription factor EB (TFEB) are strongly correlated with autophagic lysosomal characteristics 57, 58. Here, TFEB is linked to pachyonychia congenita.