For example, paclitaxel induced FOXO3 nuclear translocation to mediate its cytotoxicity and in turn promoted breast cancer cell death due to the fact that paclitaxel can promote the nuclear translocation of FOXO3 by activating c-Jun NH2 terminal kinase 1/2 (JNK1/2) in combination with inhibiting the AKT pathway and activating the pro apoptotic molecule BCL2-interacting mediator of cell death (BIM, BCL2L11) to trigger apoptosis 267, 268. This evidence concerns the gene FOXO3 and breast cancer.