Although the mechanism of lncRNA HOTAIR in PC is unknown, HOTAIR can increase the radioresistance of PC cells by down-regulating Wnt inhibitory factor 1 (WIF1) 41, which inhibits the activation of Wnt/β-catenin signaling pathway by binding Wnt protein and inhibiting its signal transduction activity in the intercellular space 42. Here, WIF1 is linked to pachyonychia congenita.