In NSCLC, both tripartite motif containing 22 (TRIM22) and troponin C1 (TNNC1), downstream factors negatively regulated by FOXO3, are up-regulated in cancer cells and gemcitabine resistant cell lines and confer gemcitabine resistance by protective autophagy 287, 288. Here, TRIM22 is linked to non-small cell lung carcinoma.