UCA1 and pachyonychia congenita: In PC, lncRNA urothelial cancer associated 1 (UCA1), which is up-regulated and can enhance the migration ability of cancer cells, regulates mitochondrial dynamics through the activation of MAPK/ERK pathway, including up-regulating mitochondrial membrane potential, enhancing mitochondrial fusion and reducing mitochondrial fission to inhibit mitophagy 89.