As a cancer-promoting factor, HMGB1 is also regulated by lncRNA small nucleolar RNA host gene 16 (SNHG16)/miR-218-5p 69 and lncRNA zinc finger E-box binding homeobox 2 antisense RNA 1 (ZEB2-AS1)/miR-204 70 axis in PC. The gene discussed is PTGDR; the disease is pachyonychia congenita.