RELA and pachyonychia congenita: In PC, hypoxia can induce the translocation of pyruvate kinase M2 (PKM2) and nuclear factor kappa B subunit 3 (p65, NFKB3) to the nucleus of PC cells, and PKM2 can activate NF-kB to mediate the transcription of HIF-1α and its target gene VEGF 197.