We found that BAX knockdown not only decreased MTUS1/ATIP1-induced mitochondrial collapse, cytochrome c release, and Cas-9/-3 and GSDME cleavage (Figure 6C-D and S6B-C), but also suppressed the pyroptotic phenotype (Figure 6E) and LDH release (Figure 6F and S6D) in HNSCC cells. This evidence concerns the gene CYCS and head and neck squamous cell carcinoma.