We also established the HNSCC cell lines with stable knockdown MTUS1/ATIP1 (Figure S1B) and found that ATP levels were significantly reduced in MTUS1/ATIP1-overexpressed HNSCC cells and increased in MTUS1/ATIP1-knockdown HNSCC cells (Figure 2F and S2E). Here, MTUS1 is linked to head and neck squamous cell carcinoma.