BAX and head and neck squamous cell carcinoma: We found that BAX knockdown not only decreased MTUS1/ATIP1-induced mitochondrial collapse, cytochrome c release, and Cas-9/-3 and GSDME cleavage (Figure 6C-D and S6B-C), but also suppressed the pyroptotic phenotype (Figure 6E) and LDH release (Figure 6F and S6D) in HNSCC cells.