The pyroptotic markers cleaved caspase-9 (Cl-Cas9), Cl-Cas3 and N-terminal of Gasdermin-E (GSDME-N), but not Cl-Cas1/7/8 or C-terminal of Gasdermin-D (GSDMD-C), were detected in MTUS1/ATIP1-overexpressed HNSCC cells. Here, GSDMD is linked to head and neck squamous cell carcinoma.