Erastin and its analogs are known as inducers of ferroptosis, a type of cell death characterized by accumulation of intracellular lipid peroxides and ROS, by inhibiting SLC7A11-mediated cystine uptake and activating the voltage-dependent anion channels (VDACs) to induce mitochondrial dysfunction in tumor cells 47-49. This evidence concerns the gene SLC7A11 and neoplasm.