Knocking down FUT8 or using 2F-Fuc (a core fucosylation inhibitor) effectively rescued B7H3-mediated immunosuppression, indicating that targeting the FUT8-B7H3 axis, particularly in combination with PD-L1, has the potential to enhance the anti-tumor immune response in patients with TNBC 74. This evidence concerns the gene CD276 and neoplasm.