GSK3B and ovarian cancer: We then examined the expression levels of key molecules in the RORα/ECM1/VEGFR2 signaling pathway in PARP inhibitor-resistant ovarian cancer cells before and after PS VII intervention, and found that PS VII significantly inhibited the expression levels of metabolism and angiogenesis-related molecules such as VEGFR2, SCL, HK2, LDHA, and FAK/AKT1/GSK3β by binding and activating RORα and regulating the downstream ECM1/VEGFR2 axis (Supplementary Figure 2H).