To further characterize the molecular features of this inflammatory response, we analysed a potential activation of NLRP3 inflammasome since it is expressed in both parenchymal and non-parenchymal liver cells and its activation has lately gained relevance in the pathogenesis of various types of liver diseases 45 although no information is available in regard to its expression or activation in HPC. Here, NLRP3 is linked to liver disorder.