Moreover, 4-HNE, MDA, and intracellular ROS levels and mitochondrial 8-OHdG (mt 8-OHdG) were significantly enhanced in the gastric mucosa or epithelial cells of PHG patients (Figure 2B, 2C), and FADD was found to be located mainly in mitochondria in the mucosa of the PHG patients and mice with PVL (Figure 2D, 2H). The gene discussed is FADD; the disease is periventricular leukomalacia.