Moreover, MT obviously relieved mucosal injury, enhanced epithelial cell viability, decreased NLRP3, cleaved caspase-1 and GSDMD-N levels, and decreased IL-1β and IL-18 production in mice with PVL without affecting the FADDosome in mice with PVL, which suggested that blockade of mtROS by MT provided protection against this epithelial NLRP3 inflammasome-mediated pyroptosis and mucosal injury in PHG. The gene discussed is NLRP3; the disease is periventricular leukomalacia.