CASP8 and periventricular leukomalacia: Moreover, MT suppressed NLRP3, cleaved caspase-1 and GSDMD-N levels and decreased IL-1β and IL-18 production in the epithelial cell of mice with PVL without affecting FADD/RIPK1/caspase-8 elements (Figure S7C, S7D), which highlights the protective role of MT in NLRP3 inflammasome activation-mediated pyroptosis and mucosal injury in PHG.