Although the protein levels of PKM2 were increased in both PHG patients and mice with PVL, while the upregulation of PKM2 was not affected by Nec-1 treatment or shFADD transfection, which suggesting PKM2 may contribute to the pathogenesis of PHG by other signaling pathways rather than FADDosome network, and this underlying mechanism needs us to uncover in our future works. Here, PCSK1 is linked to periventricular leukomalacia.