Increased levels of Fis1 localized to the mitochondria in mice with PVL (Figure 3K), and the interaction between Drp1 and Fis1 from mitochondria was enhanced in the gastric epithelial cells from mice with PVL, although Drp1 could also bind to other fission elements, such as Mid49, Mid51 and Mff (Figure 3J, 3L). Here, FIS1 is linked to periventricular leukomalacia.