CASP1 and periventricular leukomalacia: Furthermore, Mdivi-1 decreased epithelial 4-HNE levels, ROS and MDA levels, and downregulated cleaved caspase-1 and NLRP3 expression but did not affect the levels of FADD, RIPK1 or caspase-8 in epithelial cells from mice with PVL (Figure 4F).