No significant differences in FADD/caspase-8/RIPK1 signaling, Drp1 or Fis1 expression were observed between the PVL-treated NLRP3-WT and PVL-treated NLRP3-KO mice (Figure 9C, Figure S8A), while ASC, cleaved caspase-1 and GSDMD-N were obviously inhibited in the PVL-treated NLRP3-KO mice compared with those in PVL-treated NLRP3-WT mice (Figure 9D, Figure S8B). The gene discussed is CASP8; the disease is periventricular leukomalacia.