Consistently, 52.3% NLRP3+ epithelial cells were observed in mice with PVL compared to 8.38% NLRP3+ epithelial cells in SO mice without FADD knockdown according to flow cytometric analysis, and this percentage was reduced to 20.9% after FADD knockdown in mice with PVL (Figure 8F). The gene discussed is FADD; the disease is periventricular leukomalacia.