The expression of the glycolytic proteins LDHA and HK2 and the lactic acid concentration were obviously increased in the epithelial cells of the mice with PVL, while the expression of LDHA and HK2 and the lactic acid concentration were decreased by the NOX2 inhibitor GSK2795039 (Figure 7A). The gene discussed is HK2; the disease is periventricular leukomalacia.