Marked gastric injury with mucosal erosion and enhanced 4-HNE levels were observed in NLRP3-WT mice with PVL compared with those in NLRP3-KO mice, and no significant difference in FADD expression was observed between the PVL-treated NLRP3-WT and PVL-treated NLRP3-KO mice, although the FADD expression was enhanced in both of them (Figure 9A). This evidence concerns the gene NLRP3 and periventricular leukomalacia.