Some studies reveal that elevated NOX2 can induce HK2-dependent and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3)-dependent high glycolytic activity in glioblastoma multiforme (GBM) and acute myeloid leukemia (AML) cells, respectively 50, 51. Here, CYBB is linked to acute myeloid leukemia.