In this sense, there are a group of pathologies known as congenital disorders of autophagy, which are identified by monogenic mutations and include EPG5-related Vici syndrome, beta-propeller protein-associated neurodegeneration due to mutations in WDR45, SNX14-associated autosomal-recessive cerebellar ataxia and intellectual disability syndrome, and three forms of hereditary spastic paraplegia, SPG11, SPG15 and SPG49 caused by SPG11, ZFYVE26 and TECPR2 mutations, respectively 135. The gene discussed is SPG11; the disease is hereditary spastic paraplegia.