We also observed that after being cocultured with high-SNHG3 exosomes, the CRC cells presented a more mesenchymal morphology while the low-SNHG3 exosomes coculture group exhibited a more epithelial morphology compared with the control group (Fig. S2C), which indicated that SNHG3 may activate the epithelial-mesenchymal transition (EMT) to promote the proliferative and metastatic ability of CRC cells. This evidence concerns the gene SNHG3 and colorectal carcinoma.