Consistently, administration of AAV6-miR-144 agomir significantly elevated collagen and a-SMA protein expression as illustrated by Sirius red and a-SMA staining results although it didn't reach statistical significance by western blot results (Fig. 6C-D), suggesting that miR-144 may also exacerbate BDL-induced liver fibrosis. The gene discussed is SMN1; the disease is Hepatic fibrosis.