A previous study found that KLF11 inhibited Smad7 by recruiting Sin3a to its promoter, thereby enhancing TGF-β signaling pathway and exacerbating liver fibrosis 40; whereas another study confirmed that NR4A1 limited the degree of liver fibrosis by recruiting Sin3a repressor to the TGF-β target genes 32. The gene discussed is SMAD7; the disease is Hepatic fibrosis.