In IVW and MR Egger analyses, the P value of Q statistic was 0.980 and 0.992 respectively, and the I2 < 50% in both methods, indicating there was no significant heterogeneity in estimating the effect of HF on plasma LRRTM2 level (Supplementary Table 12). The gene discussed is LRRTM2; the disease is hydrops fetalis.