LMNA and Hutchinson-Gilford progeria syndrome: Figures 1A–C demonstrates similar pathological appearance between the calcific aortic stenosis seen with both HGPS and aging. Non-HGPS individuals accumulate vascular progerin with increasing age, but at much lower levels than HGPS; this could serve as a common driver of atherosclerosis between HGPS and generalized aging (3, 12).