TGFBR1 and hydrops fetalis: While we expected a synergetic effect of miR-181c-5p inhibition on cardiac fibrosis by targeting both Tgfbr1 and Smad7 in HF conditions, we found that cardiac Smad7 did not significantly differed from the HF scrambled group, and was rather downregulated instead of upregulated as seen in healthy mice.