ABR: Annualized bleeding rate; ADA: Anti-drug antibody; aPCC: Activated prothrombin complex concentrate; CVAD: Central venous access devices; EmiPref: Emicizumab preference survey; FVIII: Factor VIII; HA: Hemophilia A; Haem-A-QoL: Hemophilia-specific health-related quality of life questionnaire; HRQoL: Health-related quality of life; PH: Physical health; SD: Standard deviation; TMA: Thrombotic microangiopathy; TS: Treatment satisfaction. The gene discussed is ADA; the disease is hemophilia A.