also reported that M1-like polarization of tumor-related macrophages was aided by the HMGB1/RAGE/NF-κB/NLR family pyrin domain containing 3 (HMGB1/RAGE/NF-κB/NLRP3) pathway, and elevated levels of HMGB1 enhanced the sensitivity of glioblastoma cells to temozolomide (80). The gene discussed is AGER; the disease is glioblastoma.