Knockdown of TREM2 can reduce the polarization of M2 phenotype, causing TAMs to remodel into the M1 type, which exhibits a pro-inflammatory and immunostimulatory state, inhibits the growth as well as invasiveness of hepatic cell carcinoma (HCC) (30) and glioma cells (21), and suppresses tumor progression. This evidence concerns the gene TREM2 and glioma.