Notably, TREM2 can also act as a β-catenin regulator by promoting the proteasomal degradation of β-catenin in the cytoplasm (57) and negatively regulating the Wnt/β-catenin signaling pathway, which in turn inhibits CRC tumor progression in vivo and in vitro (58). This evidence concerns the gene TREM2 and colorectal carcinoma.