Furthermore, TREM2 is also linked to the development of metabolic diseases, and TREM2 deficiency inhibits the downstream pathway of lipid-associated macrophages (LAMs) (5), which plays an important role in the onset and progression of hypercholesterolemia, atherosclerosis, and nonalcoholic fatty liver disease (6–8). This evidence concerns the gene TREM2 and familial hypercholesterolemia.