Furthermore, TREM2 is also linked to the development of metabolic diseases, and TREM2 deficiency inhibits the downstream pathway of lipid-associated macrophages (LAMs) (5), which plays an important role in the onset and progression of hypercholesterolemia, atherosclerosis, and nonalcoholic fatty liver disease (6–8). The gene discussed is TREM2; the disease is atherosclerosis.