PLK1 and colonic neoplasm: This study revealed that remimazolam promoted the cell-cycle progression and proliferation of HCT8 colon cancer cells by upregulating CDK1, PTTG1, CDC25C, CDK4, PLK1, PCNA, Ki67, RNASEH2B, FEN1, Cyclin D1,CD44 CDK2, CDKN3, CDC45, IQGAP3, and CDK6.