While pathologist’s reports of the tumors with high allele frequency RNF43 variants showed no serrated histology, several molecular features align with the so-called serrated pathway to CRC as discussed above but lacked the characteristic hypermethylation of MLH1. Instead, carcinomas of LS-298 frequently represented mucinous subtype with occasional signet cells. The gene discussed is RNF43; the disease is carcinoma.