More interestingly, hypoxia enhances VEGF expression in either immature and mature DCs and hypoxic DCs express higher level of CXCR-4 receptor, with important implications in the tumor microenvironment and inflammation (Schioppa et al., 2003; Monaci et al., 2020; Monaci et al., 2021). This evidence concerns the gene VEGFA and neoplasm.