A knockdown study in cells showed enhanced apoptosis and proliferation inhibition in glioma cell lines, relating to changes in the level of several proteins involved in cell proliferation, survival or apoptosis, including STAT3 cleaved caspase-3 and Bcl-2.7 Additionally, STXBP5 antisense proficient GR pancreatic cancer cell lines overexpress Adgb through ADGB promotor methylation, leading to drug resistance and inhibition of cell apoptosis. This evidence concerns the gene ADGB and central nervous system cancer.