Furthermore, high Siglec‐15 protein expression statistically associated with TNM stage, and the data also consistent with the previous studies that showed the carcinogenic roles of Siglec‐15 in human cancer, for instance participating the development and progression of retroperitoneal liposarcoma,28 promoting immune evasion of acute lymphoblastic leukemia,29 and facilitating cancer cell migration of hepatoma.30 This evidence concerns the gene SIGLEC15 and hepatocellular carcinoma.