LRRK2 and hereditary elliptocytosis: In asymmetric synapses, the vesicle size in the Lrrk2−/−mice was not consistent and distributed sparsely, with some vesicles exhibiting a significantly greater diameter (Fig. 4D, asterisk in ii), which was prevalent in all groups after the TAA injection (Fig. 4D, iv–vi); in symmetric synapses, the vesicles were more sparsely-distributed in the Lrrk2−/− mice than in the other groups (Fig. 4E, i–iii) and all HE groups reported abnormal vesicle shape (Fig. 4E, iv–vi).