In the Lrrk2−/−-HE mice, LRRK2 deficiency significantly attenuated the TAA-induced injury to different brain regions, including the PFC and the dorsal STR that regulate motor function, the ventral STR that involves self-reward, and the HIP CA3 and dentate gyrus (DG) regions that modulate learning and memory. This evidence concerns the gene LRRK2 and hereditary elliptocytosis.