In the brain tissues of the Lrrk2−/−-HE mice, qPCR results showed that acute inflammatory cytokines such as IL-1β, IL-6, IL-8, TNF-α, IFN-γ were upregulated (Fig. 5F and Supplementary Fig. 3B), consistent with those of liver and peripheral circulation. The gene discussed is CXCL8; the disease is hereditary elliptocytosis.