However, the expression of Rab10 increased and its phosphorylation decreased in the Lrrk2−/−-HE mice, suggesting that in the TAA-HE mice, LRRK2 may interfere with lysosomal homeostasis by regulating Rab10 phosphorylation, thereby affecting autophagy. Here, LRRK2 is linked to hereditary elliptocytosis.