The results showed that after the TAA intervention no significant difference was found in the expression of Rab5, Rab7, Rab8 and Rab29 in the liver lysosomes among groups (Supplementary Fig. 5) and that the total Rab10 was increased in all TAA-intervened mice and significantly upregulated in the Lrrk2G2019S-HE mice and Lrrk2−/−-HE mice (Fig. 7A). This evidence concerns the gene RAB8A and hereditary elliptocytosis.