LRRK2 and hereditary elliptocytosis: Notably, the Lrrk2−/−-HE mice reported the lowest survival rate, highest blood ammonia level, and severest inflammatory cell infiltration in the hepatic portal area; no significant difference in survival rate was evident between the Lrrk2G2019S-HE mice and WT-HE mice, suggesting that LRRK2 plays a protective role in the TAA-induced ALF and HE.