In H&E staining, compared with the control group, the TAA-intervened groups displayed hepatocytic edema and ballooning, reticular fiber collapse, infiltration of inflammatory cells (mainly macrophages and neutrophils), and punctate or focal necrosis of the hepatic lobules centered on the central vein, with the most significant inflammatory changes in the liver of the Lrrk2−/−-HE mice (Fig. 2D). This evidence concerns the gene LRRK2 and hereditary elliptocytosis.