LINC00606 and central nervous system cancer: It is noteworthy that the apoptosis level of U251 cells co-transfected with the miR-486-3p mimic and LINC00606-overexpression plasmid was lower than that of U251 cells transfected with the miR-486-3p mimic alone (Fig. 3p, q), indicating that miR-486-3p increased glioma cell apoptosis but overexpression of LINC00606 antagonized this apoptosis-promoting effect.