To investigate the biological function of LINC00606 in glioma cells, the U251 and U118 cell lines were transfected with control siRNA (Control) or LINC00606 siRNA (si LINC00606) and with the control plasmid (pcDNA3.1) or LINC00606-overexpression plasmid (OE LINC00606) (Supplementary Fig. S2a, b). Here, LINC00606 is linked to glioma.