ROCK1 and inflammatory response: When mice were used as sepsis models, the mRNA and protein levels of Rho family were abnormally activated in lung, including ROCK1 and RhoC, whereas, as lung inflammation was controlled by treating with asperosaponin VI, the mRNA and protein levels of RhoC gradually returned to normal or further downregulation [22], which suggested that RhoC may be one of the indicators of lung inflammation.