HDGFL2 and malaria: Traditionally, microscopy is the gold standard, but due to the various challenges (inadequate training/experienced of microscopy readers, deficiency in personnels, sub-standard or inadequate equipment, lack of power supply etc.)that surrounds it, [12, 13] rapid diagnostic tool such as P. falciparum histidine rich protein II (HRP-2) malaria RDTs are deployed in many endemic areas where microscopy is unavailable.