Next, the expression of IGF2BPs in ESCC cell lines in the CCLE database were analyzed, and the results showed that the expression of IGF2BP1 was significantly lower than IGF2BP2 and IGF2BP3, and IGF2BP2 was highly expressed in KYSE180 and KYSE30 (Fig. 2D). This evidence concerns the gene IGF2BP1 and esophageal squamous cell carcinoma.