Additionally, another study aimed at correlating serum metabolic profiles of RA patients undergoing methotrexate treatment with synovial gene expression discovered associations between serine/glycine/phenylalanine metabolism and aminoacyl-tRNA biosynthesis with TNF-α/CD3E and B cell/plasma related signatures, suggesting a role in lymphocyte regulation within the RA synovium [58]. This evidence concerns the gene TNF and rheumatoid arthritis.