It has been observed that IGF increases the growth of human mesangial cells [23], stimulates the production of proteoglycans by human embryonic mesangial cells [24], and vascular endothelial cells [25], in in vitro conditions, as well as excessive production of this growth factor in NOD mice mesangial cells causes the accumulation of ECM [26], which demonstrates that IGF is the main factor in the progress of glomerulopathy. This evidence concerns the gene IGF1 and lipoprotein glomerulopathy.