Although in the present study, the growth of mesangial cells and the accumulation of the ECM were not measured (that is our study limitation), the less significant increase in serum Alb concentration in IT-PRP animals than in two other biomaterial-treated islets groups are partly may be due to IGF which induces glomerulopathy and partly is due to the presence of HGF/ TGF- β. This evidence concerns the gene HGF and glomerular disorder.