However, Schulz et al. (2019) describe that Tmem63c is upregulated in Munich Wistar Frömter hypertensive rats, TMEM63C is downregulated in biopsies from patients with focal glomerular sclerosis, and the glomerular filtration barrier of tmem63c zebrafish morphants or crispants is disrupted and leaky. The gene discussed is TMEM63C; the disease is focal segmental glomerulosclerosis.