This finding is in line with a study evaluating four qualitative ultrasound features (regular tumor shape, no angular or spiculated margin, posterior acoustic enhancement and no calcification) in 252 breast lesions to predict the histological grade, Ki67, HER2, axillary lymph node metastasis and lymphovascular invasion, with corresponding AUC values of 0.673, 0.680, 0.651, 0.587 and 0.566, respectively [41]. Here, MKI67 is linked to neoplasm.