To test whether ICAM1/LFA-1 interaction governs AML killing by primary CD8+ T cells, which mediate anti-AML immunity in vivo [36, 37], we co-cultured human CD8+ T cells with K562 cells, wild-type U937 cells, or U937-ICAM1-KO cells. The gene discussed is ITGAL; the disease is acute myeloid leukemia.