For AML sensitivity-associated program P1, some of the top interacting pairs included AML genes IFNGR1 and TNFRSF1B, which encode receptors for IFN-γ, TNF-α and LTA, and CD4IL10 cell cytokine genes IFNG,TNF and LTA. AML cells also upregulated integrins ITGB2 (encoding CD18), ITGAL (CD11a), ITGAM (CD11b), and ITGAX (CD11c), which can bind to ICAM1 (encoding ICAM1, also known as CD54) and ICAM2 (CD102) upregulated on CD4IL10 cells (Fig. 3C). This evidence concerns the gene TNF and acute myeloid leukemia.