To test whether ICAM1/LFA-1 interaction governs AML killing by primary CD8+ T cells, which mediate anti-AML immunity in vivo [36, 37], we co-cultured human CD8+ T cells with K562 cells, wild-type U937 cells, or U937-ICAM1-KO cells. This evidence concerns the gene ITGB2 and acute myeloid leukemia.