CD4IL10 cells co-cultured with sensitive AML upregulated T cell activation-induced genes IL2RA (CD25) and TNFRSF4 (OX40), inflammatory cytokines CSF1 (M-CSF), CSF2 (GM-CSF), IFNG, and LTA (lymphotoxin A), metabolism-related genes FABP5 and PKM, and T cell activation-induced co-inhibitory molecules HAVCR2 (TIM3) and CTLA4, among others (Fig. 3A; full list in Table S5). Here, CTLA4 is linked to acute myeloid leukemia.