The FMR cutoff value for metabolic syndrome in a Chinese population was suggested to be 0.34 for men and 0.55 for women70, and the FMR cutoff for impaired insulin sensitivity in patients with treatment-naïve type 2 diabetes in a Japanese population was found to be 2.75 (0.36 when estimated as FMR) for men and 1.65 (0.61 when estimated as FMR) for women71. Here, INS is linked to type 2 diabetes mellitus.