The FMR cutoff value for metabolic syndrome in a Chinese population was suggested to be 0.34 for men and 0.55 for women70, and the FMR cutoff for impaired insulin sensitivity in patients with treatment-naïve type 2 diabetes in a Japanese population was found to be 2.75 (0.36 when estimated as FMR) for men and 1.65 (0.61 when estimated as FMR) for women71. This evidence concerns the gene INS and metabolic syndrome.