EGFR and cancer: The results explored that DBF4 was mostly enriched in ERBB signaling pathway (p = 0.001, FDR = 0.001), WNT signaling pathway (p < 0.001, FDR = 0.003), Notch signaling pathway (p = 0.002, FDR = 0.005), MAPK signaling pathway (p = 0.003, FDR = 0.002), PI3K-AKT signaling pathway (p = 0.002, FDR = 0.002), pathways in cancer (p = 0.004, FDR = 0.005), VEGF signaling pathway (p < 0.001, FDR = 0.007), TGF-BETA signaling pathway (p = 0.002, FDR = 0.009) and suggesting that DBF4 is indeed involved in tumor development (Fig. 5B,C).