However, LRBA deficiency, even though it may not directly cause a clinically manifest gastrointestinal or endocrine pathology by itself, may render LRBA-expressing epithelial or endocrine cells more vulnerable to autoimmune attack or other forms of distress, or promote autoimmunity by autoantigen leakage, and thus contribute to the pathogenesis. The gene discussed is LRBA; the disease is Autoimmunity.