Among these twenty six pan mutation, NA was reported to have an 16 amino acid substitution (N248D, V106I, N369K, V241I, N44S, I106V, N200S, I321V, I34V/K432E, N386K, L40T, I314M and V13I/V264I/N270K) fixed in H1N1pdm09 virus population from 2009 Influenza pandemic to till 2015 to indicate their biological relevance18. This evidence concerns the gene XK and influenza.